Hydrogen Water
H2 water scavenges •OH (ESR ↓) for selective ROS balance, spares H2O2, modulates NF-κB/immunity, induces tumor apoptosis/anti-angio. Early trials (CRC/ovarian/gastric) show tox reduction without blunting therapy; 500–1500 ml/day (1–2 ppm) safe/accessible—adjunct hydration.
Forms: Bottled hydrogen-infused water (OTC, 1–3 ppm H2) · Electrolyzers/generators (home use, fresh infusion)
Key Takeaway
Molecular hydrogen–enriched water that scavenges hydroxyl radicals; early human data suggest it can reduce treatment side-effects and oxidative stress without clearly blunting anti-tumor therapy.
Evidence at a glance
Moderate clinical (early RCTs, meta on tox reduction) + strong preclinical; larger efficacy trials needed.
How it may work
Hydrogen water selectively scavenges hydroxyl radicals (OH•), reducing oxidative stress while preserving beneficial ROS like hydrogen peroxide. It modulates redox balance, enhances immune function, and inhibits tumor growth by suppressing proliferation, inducing apoptosis, and reducing angiogenesis. Studies show it alleviates chemotherapy side effects, such as cisplatin-induced nephrotoxicity, by protecting normal cells without interfering with anti-cancer efficacy. Preclinical and early human trials demonstrate effects in colorectal, ovarian, and gastric cancers.
Targets & pathways
Curated mechanistic targets reported for this agent — how it may act on cells, not proof of a clinical effect.
Often studied / combined with
Combinations reported in the literature, not a protocol or a recommendation.
- Cisplatin / Chemotherapy: Nephroprotection without efficacy loss.
Overlapping mechanisms
- ROS ↓ / •OH ↓: Avoid excess with other strong ROS scavengers; may dilute selectivity without benefit.
Safety & interactions
Severity and how well-established each signal is are shown separately. Verify everything with your oncologist or pharmacist — absence here does not mean safe.
- High-dose antioxidants (e.g., NAC)MonitorLowTheoreticalPotential additive ROS modulation; no conflicts reported.
- Cisplatin / ROS-dependent chemoConsiderBeneficialTheoreticalProtects normal cells; spares tumor efficacy.
Timing
- Freshly prepared: Consume within 30 min of infusion.
- Daily divided: E.g., 250 ml TID; around meals.
- During/after therapy: To mitigate side effects.
References
Research
No published studies for Hydrogen Water yet
New studies appear here once they’ve been reviewed. Browse all studies.
Dose: as studied, not a recommendation
Ranges seen in adjunct / practice use: 500–1500 ml (po) Trials: 500–1000 ml/day of HRW (1–2 ppm H2) for 4–8 weeks. Consume fresh; electrolyzed on-site. No HED from animals (gaseous H2 studies); human data direct. Adjunct: 1–3 L/day during chemo., H2 dissipates quickly—drink immediately after generation. Tablets/drops for infusion. Safe; monitor hydration. Not Rx; quality varies by device..
Trials studying Hydrogen Water
No actively-recruiting trials matched right now. Recruiting is not the same as proven. Search ClinicalTrials.gov →